DOIONLINE 
DOIONLINE Publish In |
International Journal of Industrial Electronics and Electrical Engineering (IJIEEE)-IJIEEE |
 Journal Home Volume Issue |
||||||||
Issue |
Volume-7,Issue-4 ( Apr, 2019 ) | |||||||||
Paper Title |
Bubble-Generating Carrier Systems for Therapeutic Applications | |||||||||
Author Name |
Hsing-Wen Sung, Wei-Lin Wan, Yu-Jung Lin, Wei-Chih Lin, Wei-Tso Chia, Kun-Ju Lin | |||||||||
Affilition |
Department of Chemical Engineering, National Tsing Hua University, Taiwan (ROC) Department of Orthopaedics, National Taiwan UniversityHospital, Hsinchu Branch, Taiwan (ROC) Department of Nuclear Medicine and Molecular Imaging Center, Chang Gung Memorial Hospital, Taiwan (ROC) | |||||||||
Pages |
48-51 | |||||||||
Abstract |
We have recently developed a few bubble-generating carrier systems forvarious therapeutic applications. We will first report a “Transformers”-like nanocarrier system that allows a poorly water-soluble drug such as curcumin to self-emulsify in the intestinal lumen, owing to the in situ CO2 evolution, to form nanoemulsions and then to be absorbed effectively, improving its oral bioavailability. Additionally, a carrier system containing NONOate and an anticancer agent CTP-11 is formulated. In an acidic, aqueous condition, NONOate decomposes and generates NO bubbles, triggering localized drug release; meanwhile, NO can be used to inhibit the expression of Pglycoproteins in tumor cells to overcome the multi-drug resistance, enhancing the efficacy of cancer therapy. An O2-generating system for the enhancement of the therapeutic efficacy of doxorubicin toward hypoxic tumor cells is also reported. Furthermore, a sustained H2S-releasesystem is established as a powerful therapeutic system for chronic wound healing in diabetic rats. Given the exciting advances that are mentioned above, we believe that these bubble-generating carriers may lead to significant technological breakthroughs in the treatment of various human pathologies. Index Terms - CO2; NO; O2; H2S; bubble-generating system | |||||||||
| View Paper | ||||||||||
