DOIONLINE

DOIONLINE NO - IJASEAT-IRAJ-DOIONLNE-8006

Publish In
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT
Journal Home
Volume Issue
Issue
Volume-5, Issue-2, Spl. Iss-1  ( May, 2017 )
Paper Title
L.Acidophillus and Bifidobacterium SPP Contribute in the Treatment of Chronic Hepatitis C Patients
Author Name
Nanis G.Allam, Mohamed L.Salem, Hassan Elbatae, Maii Moustafa Nabieh
Affilition
Microbiology section, Botany Department, Faculty of Science, Immunology and Biotechnology Unit, Department of Zoology, Faculty of Science, Center of Excellence in Cancer Research Tanta University, Hepatology, Tropical diseases medicine, Dean of Medicine faculty, Kafr elsheikh University, Egypt. Microbiology section, Botany Department, Faculty of Science, Tanta University, Egypt
Pages
44-51
Abstract
Hepatitis C virus is a major leading cause of Liver pathogenesis. Probiotics showed a natural therapeutic activity against liver disorders. The antiviral and the antibacterial responses to L. acidophilus and Bifidobacteria spp in patients with chronic hepatitis C virus is a recommended study. Patients with chronic hepatitis C were treated with probiotics capsule that contains L. acidophilus and Bifidobacterium spp. They administered one capsule per day for a month before HCV treatment, blood and urine samples were collected before and after the given treatment and they were processed for a quantitative estimation of HCV by PCR, identification of bacteria by VITEK2 system and 16S r RNA gene sequencing assay, moreover, the estimation of antibacterial activity of probiotics, as well as counts of leukocytes, CD3 + T cells and CD56 + natural killer cells. Administration of Probiotics capsule enhanced the treatment response rate to HCV treatments as IFN-α and ribavirin by 25%. It had antibacterial activity against five species of the most common bacterial infections also It increased CD3 + cells counts and CD56 + natural killer cells in chronic HCV patients. Administration of probiotics as a capsule before HCV treatment can act as a supportive supplement with antiviral and antibacterial activities. Index Terms - CD3 + ; CD56 + ; Hepatitis C virus; Lactobacillus acidophilus; Bifidobacterium bifidum.
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