DOIONLINE

DOIONLINE NO - IJASEAT-IRAJ-DOIONLNE-17670

Publish In
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT
Journal Home
Volume Issue
Issue
Volume-8,Issue-4  ( Oct, 2020 )
Paper Title
Synthesis, Characterization and Antibacterial Activity of Chalcones Derivatives from 4-hydroxyacetophenone as a Starting Material
Author Name
Hutham Mahmood Yousif Al-Labban, Ruaa Wassim Adam, Israa Noor Kadhim, Ahmed Abduljabaar Jaloob Aljanaby
Affilition
University of KUFA, Faculty of Sciences, Department of Chemistry, Iraq University of KUFA, Faculty of Science, Department of Biology, Iraq
Pages
41-45
Abstract
This research involves synthesis of some chalcones derivatives from 4-hydroxyacetophenone as starting material : The derivatives of chalcone compounds [A,B and C] has been prepared by reaction benzaldehyde derivatives like [N,N-dimethylaminobenzaldehyde,3-methoxy4-hydroxybenzaldehyde,4-bromobenzaldehyde] with 4-hydroxyacetophenone .the compound [A,B and C ] derivatives. These compounds [A, B and C ] has been characterized by melting points, [FT.IR] spectroscopy and thin layer chromatography technique (TLC) has been used for reactions steps and sequence by using solvent [benzene : methanol, 4:1]. Biological activity test for three derivative compounds was done according to antibacterial activity test against two multi-drug resistance aerobic pathogenic bacteria: Escherichia coli (E.coli) as gram negative bacteria and Staphylococcus aureus (S.aureus) as gram positive bacteria with four concentrations (50, 100, 150 and 200 mg/ml) for each derivative compounds. The derivative compound C with concentration 200 mg/ml had best antibacterial effect against E.coli and S.aureus with inhibition zone diameters 18.383 ± 0.45182 and 16.700 ± 0.26457, respectively. Keywords - 4-hydroxyacetophenon, Chalcones, Biological Activity, Escherichia coli, Staphylococcus aureus, Iraq
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