DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-5, Issue-4 ( Oct, 2017 ) | |||||||||
Paper Title |
Pipelongumine-Eluting Nanofiber Mats for Application of Drug-Eluting Stent and Anticancer Activity Against Cholangiocarcinoma | |||||||||
Author Name |
Dae-Hwan Kang, Hye Lym Lee, Jungsoo Kim, Tae Won Kwak, Young-Il Jeong | |||||||||
Affilition |
Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Gyeonnam 50612, Republic of Korea Biomedical Research Institute, Pusan National University Hospital, Pusan 49241,Republic of Korea Medical Convergence Textile Center R&D Team, GyeongbukTechnopark, Gyeongsangbuk-do 38412 Republic of Korea | |||||||||
Pages |
63-65 | |||||||||
Abstract |
Piperlongumine-eluting nanober was fabricated using poly(DL-lactide-co-glycolide) copolymer by electrospinning method for application in gastrointestinal (GI) stent to treat cholangiocarcinoma cells. Piperlongumine showed sustained release over one month in vitro. Piperlongumine eluted from nanofiber was similarly inhibited growth of cancer cells and induced apoptosis against HuCC-T1 human cholangiocarcinoma cells in vitro.Furthermroe, piperlongumineeluting nanofiber coated GI stent showed efficiently inhibition of tumor growth of HuCC-T1 tumor at tumor-xenograft study. We suggest piperlongumine-eluting nanofiber for GI stent as promising medical equipment. Keywords - Piperlongumine, nanofiber, drug eluting stent, cholangiocarcinoma | |||||||||
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