DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-5, Issue-1, Spl. Iss-3 ( Mar, 2017 ) | |||||||||
Paper Title |
Preparation of Magnetic Silica Particles for Drug Delivery and Magnetic Hyperthermia Applications | |||||||||
Author Name |
Madhappan Santha Moorthy, Subramanian Bharathiraja, Panchanathan Manivasagam, Yunok Oh, Bian Jang, Thi Tuong Vy Phan, Junghwan Oh | |||||||||
Affilition |
Marine-Integrated Bionics Research Center, Pukyong National University, Busan 608-737, Republic of Korea Department of Biomedical Engineering and Center for Marine-Integrated Biotechnology (BK21 Plus), Pukyong National University, Busan 608-737, Republic of Korea | |||||||||
Pages |
45-46 | |||||||||
Abstract |
The fabrication of nanomaterials with multifunctionality is an attractive approach to be utilized them in cancer therapy. Herein, we fabricated a magnetic mesoporous organosilica material in which the magnetic Fe 3 O 4 nanoparticles were directly integrated into the mesoporous silica pore wall frameworks rather than pore channel surfaces. The hybrid magnetic mesoporous organosilica materials were synthesized by cocondensation method by combining the Fe 3 O 4 -dopamine complexation technique and traditional mesoporous silica material synthesis processes. The prepared hybrid magnetic FeNP@DPU@MMOS material is desirable for drug delivery system and magnetic hyperthermia agent in cancer therapy. The mesoporous structural properties, drug loading/release behavior, magnetic hyperthermia ability, in vitro cytotoxicity and intracellular uptake behavior of the synthesized FeNP@DPU@MMOS materials were investigated. Keywords - Magnetic nanoparticles, Mesoporous silica, Drug delivery, Magnetic hyperthermia, Cytotoxicity. | |||||||||
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