DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-4,Issue-3, Spl. Iss-1 ( Aug, 2016 ) | |||||||||
Paper Title |
Mutation Analysis of Cd117 in Hepatocellular Carcinoma | |||||||||
Author Name |
Nicholas C. Hsu, Chih-Yuan Chung | |||||||||
Affilition |
Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Taiwan Division of Hematology-Oncology, Changhua Christian Hospital, Taiwan | |||||||||
Pages |
226-228 | |||||||||
Abstract |
The aim of this study was to investigate the presence of activating CD117 gene mutation in hepatocellular carcinoma (HCC). Twenty-two CD117 positive HCC specimens confirmed by immunohisto chemical staining and RT-PCR were analyzed. All specimens were screened for mutations in exons 9 and 11 of the CD117 gene by direct sequencing. No sequence abnormalities were detected. These results suggest that the expression of CD117 tyrosine kinase is independent of mutation in exons 9 and 11 of HCC. Keywords- CD117, Hepatocellular Carcinoma, Receptor Tyrosine Kinase. | |||||||||
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