DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
||||||||
Issue |
Volume-4,Issue-2, Spl. Iss-3 ( Jun, 2016 ) | |||||||||
Paper Title |
Design, Synthesis And Biological Evolution Of Trimethoxyphenyl Cinnamide Derivatives As Anti-Cancer Agents | |||||||||
Author Name |
Bajee Shaik, Jeevak Sopanrao Kapure, Ahmed Kamal | |||||||||
Affilition |
Medicinal Chemistry and Pharmacology, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India 2,3 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India | |||||||||
Pages |
50-52 | |||||||||
Abstract |
A series of Phenyl cinnamide derivatives, aminocinnamides (5a-h), N-phenyl ureido benzenecinnamides(PUB- CAs)(6a-h) and phenyl 4-(2-oxoimidazolidin-1-yl)benzenecinnamides derivatives(PIB-CAs) (7a-g)were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. Conjugate5a displayed potent cytotoxicity with GI50 values of 99 nM against HeLa human cervical cancer cell line which is comparable to the standard 3-methoxy Phenyl cinnamide(1). Molecular docking studies revealed that these conjugate interact and bind more efficiently at colchicine binding site of tubulin. Keywords— Phenyl cinnamide, 2-Chloroethyl urea , Cytotoxicity, Molecular docking. | |||||||||
| View Paper | ||||||||||
