DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-4,Issue-2 ( Apr, 2016 ) | |||||||||
Paper Title |
Antibacterial And Antityrosinase Activities Of Isolated Compounds From Stem Bark Of Ficus Platyphylla Del | |||||||||
Author Name |
Aminu Muhammad, Mustapha Ya’u, Hasnah Mohd Sirat | |||||||||
Affilition |
Department of Pure and Industrial Chemistry, Faculty of Science, Bayero UniversityKano,3011, Kano, Nigeria Department of Chemistry, Jigawa State College of Education Gumel, 1002, Gumel, Jigawa, Nigeria Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, Malaysia | |||||||||
Pages |
22-26 | |||||||||
Abstract |
An investigation of the chemical constituents into the stem bark of Ficus platyphylla (Moraceae) has resulted in the isolation of hordenine, epicatechin, lupeol, lupeol acetate and α-amyrin acetate. Their structures were determined using spectroscopic data as well as comparison with literature data. The antibacterial assay has been tested against Gram positive and Gram negative bacteria, while the tyrosinase inhibition assay was examined using L-Dopa as a substrate of mushroom tyrosinase enzyme. Hordenine, epicatechin, lupeol, lupeol acetate and α-amyrin acetate showed minimum inhibition concentration (MIC) values in the range of 225-900 μg/mL against the bacterial strains. Lupeol, lupeol acetate and α-amyrin acetate showed significant antityrosinase activity against mushroom tyrosinase enzyme with percent inhibition of 67.7%, 66.2% and 62.2%, respectively. Keywords— Antibacterial, antityrosinase, chemical constituents, Ficus platyphylla. | |||||||||
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