DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-4,Issue-1, Spl. Iss-2 ( Feb, 2016 ) | |||||||||
Paper Title |
Research And Biological Testing Of 99mtc-Labeled Fluoroquinolones | |||||||||
Author Name |
N.V. Varlamova, E.A. Nesterov, V. L. Sadkin, L.A. Larionova, A.E.Sazonov | |||||||||
Affilition |
National Research Tomsk Polytechnic University, 30 Lenin Avenue, 634050 Tomsk, Russia Lomonosov Moscow State University, GSP-1, Leninskie Gory,119991Moscow, Russia | |||||||||
Pages |
217-219 | |||||||||
Abstract |
The researches of creation of specified reagent for production of 99mTc-labeled fluoroquinolones were carried out. Evaluation of the reaction mixture components influence on the radiochemical purity of the produced pharmaceuticals was performed using thin layer chromatography. Functional applicability of the labeled antibiotics for diagnostics of inflammatory process was shown on experimental animals (rats) with different localization inflammation model. The toxicity degree of the produced radiochemical pharmaceuticals was evaluated, pharmacokinetics was studied, and expiration date and shelf-life were settled. Keywords- Radiochemical Pharmaceutical, Ciprofloxacin Hydrochloride (CF), Norfloxacin Hydrochloride (NF), Bacterial Inflammation, Scintigraphy. | |||||||||
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