DOIONLINE

DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-2417

Publish In
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT
Journal Home
Volume Issue
Issue
Special Issue-1   ( Jun, 2015 )
Paper Title
Synthesis Of Spiro Barbiturates Triones And Glycosides
Author Name
P. K. Gaidhane, M. K. Gaidhane, S. K. Kharkate
Affilition
Department of Chemistry, GWCOET, Nagpur, India # Department of Chemistry , Shri Lemdeo Patil Mahavidhyalaya, Mandal, Nagpur, India ##Department of Chemistry, TGPCET, Nagpur, India
Pages
1-10
Abstract
Malonic acid undergoes condensation readily with ureas to yield barbituric acids 2 which on bromination give 5,5-dibromobarbituric acids 3. Reaction of glycerol with these 5,5-dibromo barbituric acids afforded 3-Hydroxymethyl-1,4-dioxo-7,9-diaza-/ 7- aryl-7,9-diaza-/ 7,9-diaryl-7,9-diaza-spiro[4,5]deca- 6,8,10-triones 4 which are on glucosylation gives 3- O-β-D-glucopyranosyl-oxy-methyl-1,4-dioxo-7,9- diaza-/7-aryl-7,9-diaza-/7,9-diaryl-7,9-diaza- spiro[4,5]deca-6, 8,10-triones 6. The structures of the products have been assigned on the basis of 1 H NMR, 13 C NMR, FAB-MS, optical activity and elemental analysis. The title compounds are found to have antibacterial and antifungal activities. Key words: Barbituric acid, 5, 5-dibromo barbituric acid, , dioxolane, triones, glucosides
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