DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-8,Issue-4 ( Oct, 2020 ) | |||||||||
Paper Title |
Synthesis, Characterization and Biological Evaluation of Novel Triazolo- and Tetrazolopyrimidines | |||||||||
Author Name |
Fatma Al Zahraa M. Aly, Kamal F. M. Atta, Omaima O. M. Farahat, Mahmoud A. M. Nassr, Mohamed G. Marei | |||||||||
Affilition |
Chemistry Department, Faculty of Science, Alexandria University, Ibrahimia P.O. Box 426, Alexandria 21321, Egypt | |||||||||
Pages |
10-21 | |||||||||
Abstract |
2-Hydrazinyl-4,6-diphenylpyrimidine was used as an excellent precursor for the synthesis of a new heterocyclic compounds such as 9, 11, 13, 15, 20, 22 and 23. The compounds were characterized on the basis of IR, 1H-NMR, mass spectral data and elemental analysis. The newly synthesized compounds were screened for their anticancer activity against MCF-7 cell line (breast carcinoma). Some of these compounds revealed that they possess highly significant activity. Also, the synthesized compounds have been evaluated for their in vitro antibacterial and antifungal activities. Keywords - Triazolopyrimidine, Pyrazinopyrimidine, Pyrimidotriazoloindole, Pyrimidotetrazine, Tetrazolopyrimidine and Breast Carcinoma | |||||||||
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