DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
||||||||
Issue |
Volume-7,Issue-3 ( Jul, 2019 ) | |||||||||
Paper Title |
Meta-analysis of Dolphin and Human Peripheral Blood Mononuclear Cells Reveals Inflammatory Signatures Associated with Exposure to High Levels of Perfluoroalkyl Substances | |||||||||
Author Name |
Bethany J. Wolf, Diane L. Kamen, Patricia Fair, Gary Hardiman | |||||||||
Affilition |
Department of Public Health Sciences, Medical University of South Carolina (MUSC), Charleston, SC Department of Medicine, MUSC. USA School of Biological Sciences & Institute for Global Food Security, Queens University Belfast, Belfast, UK. | |||||||||
Pages |
66-72 | |||||||||
Abstract |
Currently a fundamental gap exists on how persistent organic pollutants affect humans especially those who consume high levels of seafood from contaminated coastal waters. There is an urgent need to better understand effects of these contaminants on human health in coastal communities. Elevated contaminant levels in coastal seafood will give rise to increased contaminant burdens in humans who consume coastal seafood and given the toxicity of these contaminants increase risk for immune system disorders. In this paper we describe how we assessed the effects of contaminant exposures using high-throughput RNA sequencing (RNA-seq) in peripheral blood mononuclear cells from two species, dolphins and humans. This paper presents an integrated systems biology approach to understand the adverse effects of one of these CECs PFAS on both species. Keywords - One Health, PFASs, PBDEs, PBMC, Systems Biology. | |||||||||
| View Paper | ||||||||||
