DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-6, Issue-4, Spl. Iss-1 ( Nov, 2018 ) | |||||||||
Paper Title |
Fabrication of PLGA/GELATIN Micro Particles for Control Release Bio-Substances | |||||||||
Author Name |
Patisorn Sonthirak, Narumol Kreua-Ongarjnukool, Saowapa Thumsing | |||||||||
Affilition |
Department of Industrial Chemistry, Faculty of Applied Science, King Mongkut’s University of Technology North Bangkok, Bangkok 10800, Thailand | |||||||||
Pages |
81-85 | |||||||||
Abstract |
The purpose of research was to modify gelatin microparticles with coating method for controlled release of biosubstances. Poly(lactic-co-glycolic acid) coated gelatin (PLGA/gel) microparticles was fabricated by thermal gelation and water in oil emulsion (w/o emulsion) techniques. Bovine serum albumin (BSA) was loaded PLGA/gelatin microparticles that were fabricated from emulsion technique. The surface morphologies of PLGA/gel microparticles were spherical shape and the average diameter was 12.47 ± 3.83 μm, respectively. Both of PLGA/gel microparticles were produced and the percentage of encapsulation efficiency was 94. The BSA release profiles were shown a characterized by an initial relatively rapid release period, followed by a slower release phase. The maximum cumulative released amounts of BSA from the PLGA/gel microparticles within 5 days. The result of PLGA/gel microparticles can be appropriated and applied in drug delivery system for biomedical, cosmetic and food applications. Keywords - Controlled release, Emulsion technique, Gelatin microparticles, Poly(lactic-co-glycolic acid). | |||||||||
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