DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-6, Issue-4 ( Oct, 2018 ) | |||||||||
Paper Title |
Pharmacological Evaluation of 2-(Phenyl Hydrazino Methyl) Quinazolin-4(3h)-One for Anticancer Activity Focussed on Anti-Parp Activity | |||||||||
Author Name |
Anchitha Teresa George, Winson Sam | |||||||||
Affilition |
M.Pharm, College of Pharmaceutical Sciences, Govt. Medical College, Trivandrum Assistant Professor, College of Pharmaceutical Sciences, Govt. Medical College, Trivandrum | |||||||||
Pages |
43-49 | |||||||||
Abstract |
Poly (ADP-ribosyl) polymerases (PARPs) are enzymes that catalyze the synthesis of the biopolymer Poly (ADPribose) (PAR), a post translational modification that plays an important role in genomic repair, gene transcription, energy metabolism, cell signalling etc.2-(phenyl hydrazino methyl) quinazolin-4(3H)-one, being NAD+ mimetics can act as PARP inhibitors, hence can be used as an anticancer drug. The compound is evaluated for its antiPARP activity and it showed significant anticancer property. Keywords - PARP, ARTD,PARsylation,NAD+, BRCA mutations, 4(3H)-Quinazolinone,SAR,PASSonline,2-(phenyl hydrazino methyl) quinazolin-4(3H)-one, antiPARP activity. In silico, docking | |||||||||
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