DOIONLINE

DOIONLINE NO - IJASEAT-IRAJ-DOIONLINE-13933

Publish In
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT
Journal Home
Volume Issue
Issue
Volume-6, Issue-4  ( Oct, 2018 )
Paper Title
Pharmacological Evaluation of 2-(Phenyl Hydrazino Methyl) Quinazolin-4(3h)-One for Anticancer Activity Focussed on Anti-Parp Activity
Author Name
Anchitha Teresa George, Winson Sam
Affilition
M.Pharm, College of Pharmaceutical Sciences, Govt. Medical College, Trivandrum Assistant Professor, College of Pharmaceutical Sciences, Govt. Medical College, Trivandrum
Pages
43-49
Abstract
Poly (ADP-ribosyl) polymerases (PARPs) are enzymes that catalyze the synthesis of the biopolymer Poly (ADPribose) (PAR), a post translational modification that plays an important role in genomic repair, gene transcription, energy metabolism, cell signalling etc.2-(phenyl hydrazino methyl) quinazolin-4(3H)-one, being NAD+ mimetics can act as PARP inhibitors, hence can be used as an anticancer drug. The compound is evaluated for its antiPARP activity and it showed significant anticancer property. Keywords - PARP, ARTD,PARsylation,NAD+, BRCA mutations, 4(3H)-Quinazolinone,SAR,PASSonline,2-(phenyl hydrazino methyl) quinazolin-4(3H)-one, antiPARP activity. In silico, docking
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