DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-6, Issue-1, Spl. Iss-2 ( Mar, 2018 ) | |||||||||
Paper Title |
Cytotoxic Effects of Caffeic Acid Extracted from Echinaceapurpurea on Human Gastric Cancer Cell Line | |||||||||
Author Name |
F.Moradian, A.Sadeghi, F.Sabouni, F.Sanjarian | |||||||||
Affilition |
Department of Basic Sciences, Sari Agricultural Sciences and Natural Resources University, Mazandaran, Iran Department of Molecular medicine, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran Department of Plant Bioproducts, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran | |||||||||
Pages |
7-8 | |||||||||
Abstract |
Introduction: Echinacea purpurea extract has anticancer and anti-angiogenic properties. The one of component of this plant is caffeic acid is aphenolic compound that has different properties include; antioxidant,anti-inflammatory activity, antivirus, anticancer andimmunomodulatory..Gastric cancer is one of the most common malignant diseases throughout the world, that the prevalence rates show considerable diversity of the world. Objective: In the present study, the toxic effect of caffeic acid extracted from E. purpurea on growth of gastric cancer cell line AGS were investigated. Methods: Different concentarion of caffeic acid 0,2.0 ,2.5 and 3.25mg/ml and standard caffeic acid with 0, 600, 750 and 850 mM/ml treated on AGS cell line at 24 hoursthen cell viability determined using MTT assay. Result: The result obtained from this research showed that the viability percentage after treatment of the plant extract in concentration of 2.0, 2.25 and 3.25 mg/ml and standard caffeic acid in concentration of 600, 750 and 850 mMwere 74.3, 52.6 and 25.6% as well as 81,49,27% , respectively. Conclusion: The results showed that the caffeic acid significantly and dose dependent could reduce the growth of gastric cancer cell line AGS. Keywords - Caffeic acid, Cytotoxic,Echinacea purpurea, Gastric cancer cell line | |||||||||
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