DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-6,Issue-1,Special Issue - 1 ( Feb, 2018 ) | |||||||||
Paper Title |
Optimalization of Medicament Dosage | |||||||||
Author Name |
Lubica Krajciova, Petra Priscakova, Ladislav Czako, Vanda Repiska | |||||||||
Affilition |
Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia Department of Stomatology and Maxillofacial Surgery, Faculty of Medicine UK and UN Bratislava, Ružinovská 6,821 01 Bratislava, Slovak Republic | |||||||||
Pages |
17-18 | |||||||||
Abstract |
Warfarin is one to the most common world-wide prescribed oral anticoagulants with narrow therapeutic index. An insufficient dose of warfarin may lead to the failure its antithrombotic effect, while overdose may increase the risk of hemorrhage. Genetic variability in two genes CYP2C9 and VKORC1 have a significant effect on the individual's response to the warfarin dose. The aim of our study was determine the frequency of selected single nucleotide polymorphisms in genes CYP2C9 (CYP2C9*2 and CYP2C9*3) and VKORC1 (VKORC1*2 and VKORC1*3) in Slovak population. Keywords - Pharmacogenetics, CYP2C9, VKORC1, drug response, Warfarin | |||||||||
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