DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-5, Issue-4, Spl. Iss-2 ( Dec, 2017 ) | |||||||||
Paper Title |
Combined Extract of Zizyphi Semen and Codonopsis Radix improves Synaptic Deficits and Memory Impairments in an amyloid β-induced Dementia Moue Model | |||||||||
Author Name |
Huiyoung Kwon, In Ho Jung, Kyoung Sook Kim, Jong Hoon Ryu, Dong Hyun Kim | |||||||||
Affilition |
Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Republic of Korea Department of Life and Nanopharmaceutical Science, Kyung Hee University, Hoeki-dong, Dongdaemoon-Ku, Seoul 02447, Republic of Korea Institute of Convergence Bio-Health, Dong-A University, Busan 49315, Republic of Korea Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea | |||||||||
Pages |
39-43 | |||||||||
Abstract |
Amyloid β (Aβ), a protein found in senile, is a major hallmark of Alzheimer’s disease (AD). Since Aβ causes many pathological events within the AD brain, a therapeutic target for AD is the prevention of Aβ toxicity. In the present study, we tested whether a combined extract of Zizyphi Semen and Codonopsis Radix (ZSCR) prevented Aβ-induced aberrant synaptic plasticity and memory impairments. In Aβ-induced LTP deficit experiments, ZSCR ameliorated Aβ- induced LTP deficit in a concentration-dependent manner (P< 0.05). ZSCR also ameliorated object recognition and passive avoidance memory impairments induced by Aβ. These results suggest that ZSCR may be a good candidate for preventing and ameliorating memory deficits in patients with AD. Keywords - Amyloid β (Aβ), Codonopsis Radix, Long-term potentiation (LTP), Memory.Zizyphi Semen. | |||||||||
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