DOIONLINE 
DOIONLINE Publish In |
International Journal of Advances in Science, Engineering and Technology(IJASEAT)-IJASEAT |
 Journal Home Volume Issue |
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Issue |
Volume-5, Issue-4, Spl. Iss-1 ( Nov, 2017 ) | |||||||||
Paper Title |
Efficiency of Folate-Decorated Methotrexate Nanoparticles in MCF-7 | |||||||||
Author Name |
Ousanee Issarachot, Jiraphong Suksiriworapong, Kittisak Sripha, Mikihisa Takano, Ryoko Yumoto, Varaporn Buraphacheep Junyaprasert | |||||||||
Affilition |
Pharmacy technician department, Sirindhron college of public health of Suphanburi, 77 moo 4 TubteelekMuangSuphanburi, 72000 Department of Pharmacy, Faculty of Pharmacy, Mahidol University, 447 Sri-Ayutthaya Road, Rajathavee, Bangkok 10400, Thailand Center of Excellence in Innovative Drug Delivery and Nanomedicine, Faculty of Pharmacy, Mahidol University, 447 Sri- Ayutthaya Road, Rajathavee, Bangkok 10400, Thailand Department of Chemistry, Faculty of Pharmacy, Mahidol University, 447 Sri-Ay | |||||||||
Pages |
77-79 | |||||||||
Abstract |
This study aim to prepare targeted nanoparticles from tri and di-block copolymer of PEGylatedP(CL) and investigate in vitro study in MCF-7. MTX conjugated copolymers at 10% and subsequently decorated with FOL-conjugated copolymers at 5 were prepared from PCL-PEG-PCL (tri-block pattern) and mPEG-PCL (di block pattern) via click reaction. After that, non-targeted and targeted nanoparticle were prepared by dialysis method. Four type of nanoparticles were investigated their characteristics and cytotoxicity. The results found that the targeted nanoparticles were toxic to MCF-7 than non-targeted nanoparticles. Moreover, targeted nanoparticles form tri-block pattern were effective than di-block nanoparticles due to the different formation of nanoparticles. Keywords - Targeted nanoparticles, methotrexate, folic acid, MCF-7 | |||||||||
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